Current Issue : July- September Volume : 2012 Issue Number : 3 Articles : 12 Articles
Cocculus hirsutus, another medicinal herb from Indian herbal garden. Almost all the parts of this plant have medicional values and are used traditionally in treating various ailments like eczema, lymphedenopathy, abdominal disorders. In the recent days this has been employed in the formulation of pharmaceutical products which has drawn the attention of formulation researchers in exploring several other uses of cocculus. The present review mainly focus on the pharmacological, phyto chemical, ethno botanical, pharmacological uses of patalagarudi....
The present study was aimed to evaluate antibacterial capacity of Chrozophora rotteleri plant extracts. Antibacterial activity was evaluated on eight bacterial strains by using cup plate method. The extracts were produced concentration dependent antibacterial activity. All extracts showed good zones of inhibition against gram –ve organisms than gram +ve organisms. Methanol extract showed significant activity and hexane extract produced low zones of inhibition against bacterial strains. From the results obtained during the study it could be concluded that extracts of Chrozophora rotteleri have antibacterial components. Further is necessary for isolation and characterization of bioactive molecules which are responsible for antibacterial activity....
The present study was conducted that Acalypha betulina L. leave has hepatoprotective as well as antioxidant activity. A study was designed using alcoholic extracts of Acalypha betulina leave produce significant hepatoprotective and antioxidant activity. The activity was tested in wistar albino rats at dose levels of 125, 250 & 500 mg/kg, orally and compared with ranitidine (50 g/kg) as standard. During the ulcer condition, there was an increase in gastric mucosal SOD and LPO levels. This indicated that the generation of relative oxygen species during stress might be the causative factor for the inactivation of gastric peroxidase. The alcoholic leaves extract of Acalypha betulina has shown ulcer protective effect as dose dependently against pylorus-ligation, ethanol, cold restraint stress, and aspirin-induced gastric ulcer in rats. The said extract of Acalypha betulina was found to decrease ulcer and acid pepsin secretion. A change was also seen in SOD, CAT, and LPO levels in rat gastric mucosa due to antioxidant property of alcoholic leaves extract of Acalypha betulina Antioxidant defense mechanism of the extract was probably due to metabolising lipid peroxides and scavenging H2O2....
The hydroalcoholic extract of Yelaathi chooranam was evaluated for its antiulcer activity against aspirin and pyrolus ligation induced gastric ulcer (antisecretary) in albino rats. We found that hydroalcoholic extract at a dose of 230mg/kg p.o markedly decrease the incidence of ulcers. The extract shows significant reduction in gastric volume, total acidity, ulcer score and %of inhibiton. The plant extracts posses’ significant gastro protective activity as compared with standard drug....
Morus Alba (Moraceae) popularly knew as ‘Tutam’ in Sanskrit. The tree is moderate in size, up to 3m high 1.8m in girth. That has been widely used as astringent, anthelmentics & purgative. Nevertheless the available scientific information is very less about this species and related to its possible effect. In this work, methanolic extract of leaves of M.alba were evaluated in experimental animal using different models. The extract (300 mg/kg) was tested for its anti-diarrheal activity. The induction of increase motility by castor oil, gastrointestinal motility in rats.LD50 values were established and 1/5 dose of the methanolic extract. Antidiarrhoeal potential of extracts was evidenced by significant (p<0.001) reduction in fecal output in castor oil induced diarrhea and also a significant (p<0.001) decrease in propulsive movement of gastrointestinal contents....
The current study to investigate the antimicrobial potential of Acalph Acalypha betulina a berulina L plant. Fresh plants with authentication were selected for antimicrobial assays. Extract of stem and stem bark was extracted in hexane by means of a Soxhlet device. It was then undertaken for determination of antimicrobial activity against bacteria such as Candida albicans, Staphylococus Aureus, Escherichia coli, K.pneumoniae, P.aeruginosa and B.subtilis. MIC was found to be 15mg/ml at this concentration stem bark extract showed remarkable antibacterial activity as compared to stem extract and their zone of inhibition compared with standard antibiotics. The bacterial strain of S. aureus and E. coli showed 17mm and 22mm zone of inhibition respectively that of ampicillin and streptomycin showed very less inhibition. Stem bark also sensitive to yeast fungus Candida albicans, reported a 16mm zone of inhibition, which was moderate as compared to fluconazole. Phytochemical screening of extract showed presence of steroid and triterpenes. Thus, the current investigation leads to fresh sources of new antimicrobials in future....
Oxidative stress induced by alloxan has been shown to damage pancreatic β-cell and produce hyperglycemia in rats. Acalypha indica leaf extract is being used as a traditionally in the treatment of diabetes. The present study examined the effect of ethanolic extract of Acalypha indica against diabetic rats. An ethanolic extract of Acalypha indica was found to reduce fasting blood glucose in alloxan diabetic rats Diabetic rats treated with 100 mg/kg and 200 mg/kg showed a significant reduction in fasting blood glucose level, expressed as 44.91% and 46.90% change respectively. The maximum reduction (58.80%) was observed with the treatment of AIEExt at 400 mg/kg dose, after 14th days of treatment schedule. Oxidative stress produced by alloxan was found to be significantly lowered by the administration of Acalypha indica ethanolic extract. This was evident from a significant decrease in lipid peroxidation, glutathione peroxidase levels increased in serum as well as glycogen level was found to be increased in liver. The Acalypha indica had exhibited potential antidiabetic and antioxidant activity in alloxan-induced diabetic model through reducing oxidative damage by dose dependent manner....
An antioxidant is a chemical that prevent the oxidation of other chemicals. They protect key cell components by neutralizing the damaging effect of free radicals, which are natural by production of cell metabolism free radicals are form when oxygen is metabolized. In the body oxygen is essential for the survival of aerobic cell but it has long been known to be toxic to them when supplied at concentration greater than those in normal air. A lot of research is being carried out worldwide directed toward finding natural antioxidants of plant origin. Methanolic extracts of Macrotyloma uniflorum seed were investigated for its free radical scavenging property by different in-vitro models i.e. 1,1-diphenyl-2 picrylhydrazyl (DPPH), and reducing power. Methanolic extracts of Macrotyloma uniflorum seed shows free radical scavenging propertyless than Ascorbic acid and that used as standard antioxidant. It is evident from our study that the methanolic extract have shown dose dependent increase in free radical scavenging activity....
Antioxidants are substances that may protect cell from the damage caused by unstable moleculesknown as free radicals. Antioxidants have the ability to protect organisms from damage caused by free radical-induced oxidative stress. A lot of research is being carried out worldwide directed toward finding natural antioxidants of plant origin. Methanolic extracts of the plantFagonia indica Burm were investigated for its free radical scavenging property by different in-vitro models i.e. 1,1-diphenyl-2 picrylhydrazyl (DPPH), and reducing power.Methanolic extracts of the plant Fagonia indica Burm shows free radical scavenging propertyless than Ascorbic acid and that used as standard antioxidant. It is evident from our study that the methanolic fractions have shown dose dependent increase in free radical scavenging activity....
The leaves of Morus alba Linn. (Family: Moraceae) commonly known as mulberry are mainly used as food for the silkworms and they are sometimes eaten as vegetable or used as cattle fodder in different parts of the world. Morus alba has potential source of food diet and natural antioxidants. It contains major nutritional components and sufficient quantities of essential macro-(K, Ca, Mg and Na) and micro-(Fe, Zn, and Ni) elements. It has a unique nutritional profile containing proteins, phenolics, flavonoids and anthocyanins that enhances its significance as promising nature''s functional tonic. The phytochemical screening revealed the presence of carbohydrate, Amino acids, glycoside, phytosterols, alkaloids, tannins, steroids, flavanoids and saponin. It is known for its number of pharmacological activities like hepatoprotective activity, antidiabetic activity, Immunomodulatory property, antiulcer activity, anti-dopaminergic activity, hyperlipidemic activity and antimicrobial activity against both gram positive and gram-negative bacteria. The fruit possesses tonic effect on kidney energy and used to check urinary incontinence, dizziness, diabetes, pre-maturing gray hair, and constipation in the elderly and while leaves are antibacterial, astringent, diaphoretic, hypoglycaemic, odontalgic and ophthalmic which are used to treat sore throats, colds, eye infections, and nose bleeds. Mulberry leaves as protein source in food formulations and neuroprotective functions can be used against neurodegenerative disorders such as Alzheimer and Parkinsonism. Chemopreventive potential has been highlighted in some studies but still researchers should pay attention to validate the findings to enhance meticulousness....
Standardization of herbal formulations is essential in order to assess the quality of drugs, based on the concentration of their active principles, physical and chemical standards. This article reports on standardization of a polyherbal siddha formulation in different marketed formulations and in-house formulation which is used as anti-ulcer. Specific morphological parts of the plants are used in the polyherbal formulation. Polyherbal formulation has been standardized on the basis of organoleptic properties, physical characteristics and physic-chemical properties....
The aqueous, methanolic and saponin extracts of Zizyphus nummularia (Z. Rotundifolia) bark were screened for spermicidal activities against human spermatozoa. Extracts were found to produce significant inhibition of sperm motility and cause reduction in viability of sperm cell. Reduction in Hypo-osmotic Swelling (HOS test) indicates the possibility of plasma membrane disintegration. Saponin extract is found to be more active to cause immobilization then aqueous and methanolic extract....
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